My main research interest is understanding the mechanisms and regulation of DNA, RNA, and protein modifications. Presently, I have a particular interest in developing methods that support the detection and understanding of these modified sites. Nanopore sequencing currently has the capabilities to detect RNA and DNA modifications. I am working on developing algorithms which can better classify the presence of these modified nucleotides in the ionic current signal.
Research center
CGS@SEMM
Biografia
Education
Title: PhD
Institute: University of California Santa Cruz
Location: Santa Cruz
Country: United States
From: 2012 To: 2020
Title: Bachelor
Institute: University of California Santa Cruz
Location: Santa Cruz
Country: United States
From: 2008 To: 2012
All Publications
2021
Nivala J., Mulroney L., Luan Q., Abu-Shumays R., Akeson M.
Unfolding and Translocation of Proteins Through an Alpha-Hemolysin Nanopore by ClpXP
Nanopore Technology. Methods in Molecular Biology, Publisher: Humana, New York, NY
2020
Mulroney L.
Identification of full-length transcript isoforms using nanopore sequencing of individual RNA strands
PhD Thesis
PhD Thesis
Book
2019
Smith AM., Jain M., Mulroney L., Garalde DR., Akeson M.
Reading canonical and modified nucleobases in 16S ribosomal RNA using nanopore native RNA sequencing
PLoS ONE, vol. 14, (no. 5), pp. e0216709
2014
Nivala J., Mulroney L., Li G., Schreiber J., Akeson M.
Discrimination among protein variants using an unfoldase-coupled nanopore
ACS Nano, vol. 8, (no. 12), pp. 12365-12375
