The main mission of Computational and Chemical Biology is to develop innovative computational tools and algorithms to enhance the discovery of novel and better medicines. A further strategic asset of our research line is to design, synthesize, and biologically evaluate novel lead candidates for cancer, neurodegenerative diseases, and neglected tropical diseases. The team is composed of a core of computational scientists, who work in strict collaboration with chemists and biologists towards interdisciplinary goals in drug discovery.
Computational and Chemical Biology
Projects
Progetto 5000genomi@VdA, supported by Programma Investimenti per la crescita e l’occupazione 2014/20 (FESR) and Programma Investimenti in favore della crescita e dell’occupazione 2014/20 (FSE) Per maggiori dettagli si veda il sito del Progetto www.5000genomivda.it
The latest publications
2026
Rinaldi F., Veronesi M., Masi M., Andonaia A., Varignani G., Catalano F., Marotta R., Girotto S., Cavalli A.
A chemical biology probe identified through 19F-NMR induces RAD51 polymerization and perturbs BRC4 engagement
EMBO Workshop Chemical biology 2026
2026
Rinaldi F., Veronesi M., Masi M., Andonaia A., Bosio S., Varignani G., Catalano F., Marotta R., Falchi F., Girotto S., et al.
A chemical biology probe identified through 19F NMR screening stimulates RAD51 oligomerization and disrupts BRC4 binding
Division of Chemistry of Biological Systems Italian Chemical Society Conference 2026
2026
Rinaldi F., Veronesi M., Andonaia A., Varignani G., Marotta R., Girotto S., Cavalli A.
A fragment identified by 19F NMR stabilizes RAD51 fibrils and antagonizes BRC4 binding
50th FEBS Congress
People
Principal Investigator
Computational and Chemical Biology
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